N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide
Pluripotin
CAS: 839707-37-8
Molecular Formula: C27H25F3N8O2
N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide - Names and Identifiers
N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide - Physico-chemical Properties
| Molecular Formula | C27H25F3N8O2 |
| Molar Mass | 550.53 |
| Density | 1.43 |
| Solubility | DMSO: soluble10mg/mL (clear solution) |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | -20°C |
| In vitro study | SC1 is a dual inhibitor of ERK1 and RasGAP. Simultaneous inhibition of the activity of these proteins is a sufficient requirement for SC1 to exert its effect on mES cells. SC1 activates Ras by inhibiting the function of RasGAP. SC1 increases the efficiency of derivation and pluripotency of stem cells isolated from C57BL/6 mice. Three types of pluripotent stem cells (fES, ntES, and iPS cells) co-incubated with SC1 can efficiently generate full-term pups. |
N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.816 ml | 9.082 ml | 18.164 ml |
| 5 mM | 0.363 ml | 1.816 ml | 3.633 ml |
| 10 mM | 0.182 ml | 0.908 ml | 1.816 ml |
| 5 mM | 0.036 ml | 0.182 ml | 0.363 ml |
Last Update：2024-01-02 23:10:35
N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide - Reference Information
| biological activity | pluri bitin (SC1) is a dual inhibitor of ERK1 and RasGAP, the Kd values were 98 nM and 212 nM, respectively. It can be used to maintain the self-renewal of embryonic stem cells. Pluribitin also inhibited RSK1, RSK2, RSK3, and RSK4 with IC50 values of 0.5 μm, 2.5 μm, 3.3 μm, and 10.0 μm, respectively. |
| Target | Value |
| RSK1 () | |
| ERK1 (Cell-free assay) | 98 nM(Kd) |
| RasGAP (Cell-free assay) | 212 nM(Kd) |
| RSK1 (Cell-free assay) | 0.5 μM |
| RSK2 (Cell-free assay) | 2.5 μM |
Last Update：2024-04-10 22:29:15
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Product Name: Pluripotin Visit Supplier Webpage Request for quotationCAS: 839707-37-8
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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